Chromatin remodeling enzymes are mobilized by Xist repeat deletion.
Abstract
We recently demonstrated control of DNA damage signaling by Xist, as deletion of an Xist element resulted in H2AX silencing. We present evidence here for interaction of Xist with the nuclear chromatin remodeling machinery. BANF1 and a SWI/SNF component were silenced concurrent with H2AX silencing resulting from Xist element deletion. Xist mobilization of chromatin remodeling enzymes is likely multi-layered and complex.
Fields of Study & Subjects
Genomics and Chromatin Dynamics
Chromatin Remodeling and Cancer
DNA Repair Mechanisms
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 12 March 2026
- Language
- EN
- Document type
- Preprint