PGLYRP1 might function as an adapter that facilitates the suggested binding function of NOD2 to muramyl dipeptide.

Innate immune signaling occurs through pattern recognition of microbial or danger-associated ligands. We present evidence here that the physiologic relevance of PGLYRP1 has been partially retained over the course of metazoan and vertebrate evolution, including transcriptome data illustrating the importance of the PGLYRP1 family in human disease involving aspects of peptidoglycan recognition, in septic shock and in IBD. We present transcriptional network and biochemical evidence suggesting PGLYRP1 might function as an adapter that facilitates the suggested binding function of NOD2 to muramyl dipeptide.