Formulation, development and characterization of Vildagliptin ethosome formulation

Abstract:The objective of current study was to prepare and optimize the ethosomal drug deliverysystem for Vildagliptin (VLD) to improve the efficacy, sustain release of the drugs and superiorpatient consent. Ethosomes where prepared by Prepared by cold method using ethanol. Lecithinand cholesterol in different concentration. ethosomes were evaluated for vesicle size,polydispersity index, zeta potential, entrapment efficiency and surface morphology. The in vitropermeability studies were done using franz diffusion cell using cellophane membrane. The vesiclesize of all the formulation ranges from 115.1 ± 1.5278 nm to 686.3 ± 3.4521 nm. The smallestvesicle size (115.1 ± 1.5278 nm) was present in VF6 formulation with composition 35% ethanol,2.5% soya lecithin and 2% cholesterol. The entrapment efficiency of VF6 formulation was foundto be highest i.e 74 ± 2.432 % and it ranges from 40 ± 1.361% to 74 ± 2.432%. SEM analysis ofthe optimized VF6 shows that the vesicle are uniform in shape and size with homogeneousdispersion as can be seen from polydispersity index value of 0.230 ± 0.011. Formulation VF6showed 6 fold higher (p