Synthetic lethal relationship between Ezh2 and Parp1 in cancer cells.

Zenodo (CERN European Organization for Nuclear Research) 2026 Preprint Open access

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Authors: Shahan Mamoor
DOI: 10.5281/zenodo.19002363
Cited by: 0

Abstract

By measuring cell death following loss of gene function using whole transcriptome technologies we observed a strong, synthetic lethal relationship between the Poly (ADP-ribose) polymerase Parp1 and the H3K27 methyltransferase Ezh2. Parp1 chemotherapeutic regimens may benefit from adjunctive Ezh2 inhibition.

Fields of Study & Subjects

PARP inhibition in cancer therapy Epigenetics and DNA Methylation Chromatin Remodeling and Cancer

Publication details

Journal / source
Zenodo (CERN European Organization for Nuclear Research)
Publication date
13 March 2026
Language
EN
Document type
Preprint