THE POSSIBLE AMELIORATIVE EFFECT OF VITAMIN E AGAINST TOXICITY INDUCED BY MONO SODIUM GLUTAMATE ON THE DORSAL SURFACE OF THE TONGUE IN ALBINO RATS

Abstract Introduction: Although monosodium glutamate (MSG) is commonly employed in the food industry, its possible toxic effects remain a concern. Vitamin E (Vit E), a strong lipid-soluble antioxidant, offers potential protection against oxidative damage caused by MSG exposure. Aim: To evaluate the protective effect of vitamin E against MSG-induced structural and molecular alterations in the dorsal surface of the tongue in albino rats. Materials and Methods: Thirty adult male albino rats were randomly assigned into three groups (n=10): Group 1 (Control) received saline for 40 days; Group 2 (MSG) received MSG (60 mg/kg/day) for 30 days; Group 3 (Vit E+MSG) received vitamin E (200 mg/kg/day) for 10 days prior to, and during, MSG administration. Tongue specimens were examined histologically, immunohistochemically for inducible nitric oxide synthase (iNOS), and by qRT-PCR for heme oxygenase-1 (HO-1) expression. Results: In MSG treated group, there was marked degeneration of filiform, fungiform, and circumvallate papillae with inflammatory infilteration. There was significant increase in iNOS immune reactivity (p