Analysis code for age-dependent amplification of resting-state brain-state entropy in neurodevelopmental conditions
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This repository contains the analysis code for a manuscript examining age-related amplification of resting-state brain-state entropy in ADHD. The code implements a Markov-based dynamic functional connectivity pipeline applied to resting-state fMRI data from the ADHD-200 multi-site dataset (569 participants, 738 run-level observations; ADHD = 214, TD = 355). The workflow includes sliding-window correlation, k-means brain-state estimation (K = 6), computation of Markov metrics (switch rate, dwell time, state entropy, transition entropy, and stickiness), covariate-adjusted OLS regression with site fixed effects and site-clustered robust standard errors (G = 6 sites), and Group × Age moderation analyses with simple slopes. See README.md for execution instructions, input/output descriptions, and analysis order.
Fields of Study & Subjects
Functional Brain Connectivity Studies
Attention Deficit Hyperactivity Disorder
Mental Health Research Topics
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 20 March 2026
- Language
- EN