Evaluation Of Developmental Toxicity of Guaifenesin Using Pregnant Female Rats

Objectives: Guaifenesin has anticonvulsive, muscle relaxant, and expectorant qualities. To the best of our knowledge, there is a dearth of encouraging information about guaifenesin's developmental toxicity. Using female rats, the current study thoroughly examines the harmful effects of guaifenesin on development. Materials and Methods: Five groups of twenty-five dams were created. Groups 2, 3, 4, and 5 received 250, 350, 500, and 600 (mg/kg b.w.) doses of guaifenesin, respectively, from gestation day 6 to day 17, with Group 1 acting as a control. Of all the retrieved fetuses, half underwent skeletal examination and the other half underwent morphologic and morphometric analysis.Five groups of twenty-five dams were created. Groups 2, 3, 4, and 5 received 250, 350, 500, and 600 (mg/kg b.w.) doses of guaifenesin, respectively, from gestation day 6 to day 17, with Group 1 acting as a control. Of all the retrieved fetuses, half underwent skeletal examination and the other half underwent morphologic and morphometric analysis.