Colitogenic potential is governed by quality and quantity of homeostatic control.
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We describe for the first time the principle that mutations and variants with colitogenic potential, that result in GI tract-based autoimmune disease, are essentially different than those that do not. Two major IBD risk factors are NOD2 and Atg16l1. We recently described mechanisms of homeostasis control by NOD2. Here we compared using advanced transcriptomic methods relative degree of homeostatic control by Atg family members that function in autophagy. The data together demonstrate that colitogenic potential is governed by quality and quantity of homeostatic control.
Fields of Study & Subjects
Inflammatory Bowel Disease
Gut microbiota and health
Autophagy in Disease and Therapy
Publication details
- Journal / source
- Zenodo (CERN European Organization for Nuclear Research)
- Publication date
- 16 March 2026
- Language
- EN
- Document type
- Preprint