Cryo-Coupling: Geometric Cancer Intervention via Phase-Locked Descent of the 25×N Ladder

Proposes a non-destructive cancer intervention framework grounded in the geometric composition equation. Rather than fighting cancer by destroying tissue, the protocol couples to the cancer's coupling state and walks it back down the T1 = 25×N ladder. Two-pronged mechanism: (1) localized mild hypothermia (28-32°C, not ablative) reduces coupling density d, targeting the impaction (Da) domain; (2) GLP-1 receptor agonist compound delivered locally during cooling induces Z-DNA formation at overactive cancer promoters, creating targeted transcriptional deadlock in the radiation (Dum) domain. Combined: phase-locked descent stepping 25×12 = 300 ms per treatment cycle. Tissue survives; coupling state changes. Six falsifiable predictions including quantized T1 steps, synergistic cryo-GLP-1 response, and fat-tissue negative control. GCT Research Protocol II.