FDS-B0: Biomedical Bridge Registry

Official website: distinctiontheory.orgPublic portal for the start guide, papers, claim status, failure registry, prior-art boundary, and citation resources. Canonical GitHub repository:https://github.com/yiningwu-research/Distinction-Theory A Non-Clinical Framework for Boundary Maintenance, Disease-Model Translation, and Safety Firewalls in Finite Distinction Systems FDS-B0 serves as the foundational governance and protocol paper for the Biomedical Bridge Series (B-series) within the Distinction Theory (DT) framework. It establishes the rigorous criteria under which the formal logic of Active Finite Distinction Systems (FDS) can be mapped onto biological and biomedical phenomena without crossing into unauthorized clinical territory. Core Contributions: Maintenance Debt Framework: Defines a unifying systems-theoretic theme for aging, cancer, and chronic disease as the accumulated mismatch between biological repair demand and regulatory capacity. Biomedical Translation Barrier: Implements a structural "firewall" (FDS Interpretation ≠ Clinical Action) to ensure theoretical models are used for hypothesis generation and systems-level organization only. Causal-Topology Layer: Positions FDS as a non-reductive model layer that complements, rather than replaces, validated molecular mechanistic pathways. Standardized Reporting Protocols: Introduces the Biomedical Bridge Claim Card and Safety Firewall Card to ensure all downstream B-series applications (Immunity, Oncology, etc.) remain auditable, falsifiable, and ethically compliant. Translation Readiness Levels (TRL): Establishes a 5-tier classification system for theoretical claims, ranging from "Conceptual Only" to "Preclinical Research Candidate." Scope: Living systems are modeled non-clinically as active, finite, boundary-maintaining systems under repair, verification, and resource constraints. This registry provides the audit grammar necessary for applying the FDS cost chain—from capacity deficit to Phase-C collapse—to the complexities of life sciences. Note: This is a systems-theoretic research document. It does not provide medical advice, diagnosis, or treatment guidance. It is intended for researchers in systems biology, theoretical medicine, and complex systems. Part of the Distinction Theory Corpus.Companion to: Active Finite Distinction Systems: A Formal Core for Boundary Maintenance under Finite Capacity.