TOGT/GTCT Translational Applications — Preprint Series: RNA Riboswitches, NGS Bridge Amplification, and Microtubule Curvature (Domains 1–3)

Three companion preprints applying the TOGT/GTCT contact-geometric operator framework (Principia Orthogona series, DOI 10.5281/zenodo.19117399) to three biological domains. Each preprint contains the problem statement, operator mapping, falsifiable quantitative predictions, experimental protocols, and 6-panel domain-specific figures. Domain 1: aminoglycoside resistance riboswitches (AAC/AAD leader RNA; κ* modulation; antagonist OFF-lock predictions). Domain 2: NGS bridge amplification on Illumina flow cells (κ_NGS derivable from DNA persistence length and primer spacing; Whitney A₁ bifurcation at cluster quality boundary). Domain 3: microtubule curvature dynamics in volatile anesthesia and neuroprotection (classical κ shift mechanism distinguishable from Orch-OR; epothilone B LORR delay prediction). Also includes the dm³ Python simulation (DOP853, rtol=1e-10) reproducing all figures. Lean 4 source: github.com/TOTOGT/AXLE.