CAASm1A/m1A: N1-methyladenosine mRNA Methylation in Arabidopsis

N1-methyladenosine (m1A) is a recently identified mRNA methylation mark that affects gene expression and translation. In the model plant Arabidopsis thaliana, its landscape and function remain uncharacterized. Here, we present base-resolution m1A methylomes across diverse Arabidopsis tissues and show that m1A is enriched in 5′ UTR and preferentially localizes to highly expressed genes, negatively correlating with mRNA translation.