Study 30 — Trichomonas vaginalis Co-infection and Cervical Cancer Progression: HPV Interaction and Global PAF

Study 30 of the Hidden Infections research series. Trichomonas vaginalis co-infection with human papillomavirus (HPV) is associated with elevated risk of cervical intraepithelial neoplasia and invasive cervical cancer progression. T. vaginalis disrupts cervical epithelial barrier function, enhances HPV persistence, and drives local IL-8-mediated inflammation. This study documents the co-infection epidemiology, mechanistic evidence for TV as an HPV progression co-factor, and PAF estimates for TV-attributable cervical cancer globally. CC0 public domain. AI-assisted draft pre-print.