Nicotinamide Riboside, an NAD precursor and supplement, reduces liver damage caused by sepsis

Sepsis leads to liver failure and eventually death. The supplement nicotinamide riboside is an antioxidant and nicotinamide adenine dinucleotide precursor. This study aimed to evaluate the therapeutic effect effect of nicotinamide riboside on liver injury in a rat sepsis model induced by cecal ligation and perforation. 21 rats were divided into 3 groups: control, sepsis and sepsis+ nicotinamide riboside group. Cecal ligation and perforation applied to sepsis and sepsis + nicotinamide riboside groups. Nicotinamide riboside applied to sepsis + nicotinamide riboside group orally (200 mg·kg-1) 1 hour (h) before and 12 h after cecal ligation and perforation. 24 h after cecal ligation and perforation, rats sacrified. Histopathological and biochemical parameters were analyzed. Nicotinamide riboside treatment resulted in a decrease in high levels of aspartate and alanine aminotransferases, creatine, and ceruloplasmin. Serum albumin, calcium, and amylase levels were decreased in sepsis group and increased in sepsis + nicotinamide riboside group (P