Pallidal Deep Brain Stimulation for Tremor Control in a Child with Juvenile DNAJC6-Associated Parkinsonism
Abstract
Background: Juvenile DNAJC6-associated Parkinson's disease is a rare cause of early-onset parkinsonism with limited treatment data. Case Report: We describe a 15-year-old female with a novel DNAJC6 variant presenting with progressive tremor, bradykinesia, and postural instability. Although initially responsive to levodopa, she developed severe medication-induced motor fluctuations refractory to multiple pharmacological therapies. Due to disabling tremor, bilateral globus pallidus internus deep brain stimulation (GPi-DBS) was performed, resulting in marked and sustained tremor reduction. Discussion: This case highlights the severe course of DNAJC6-associated juvenile parkinsonism and supports GPi-DBS as an effective option for refractory tremor.
Fields of Study & Subjects
Neurological disorders and treatments
Parkinson's Disease Mechanisms and Treatments
Parkinson's Disease and Spinal Disorders
Publication details
- Journal / source
- Tremor and Other Hyperkinetic Movements
- Publisher
- Ubiquity Press, Ltd.
- Volume
- 16
- Issue
- 1
- Pages
- 32–32
- Publication date
- 1 January 2026
- Language
- EN