PROMINENT PHENOTYPE IN RECENT YEARS: EOSINOPHILIC ASTHMA
Abstract
Asthma is a heterogeneous disease characterized by chronic airway inflammation. In recent years, the eosinophilic asthma phenotype has emerged as a prominent subtype, particularly among patients with severe disease. Eosinophilic asthma is a type 2 (T2)-high asthma phenotype marked by elevated eosinophil levels in peripheral blood, sputum, and airway tissue, driven by both genetic predisposi-tion and environmental triggers. Cytokines such as interleukin (IL)-5, IL-4, and IL-13 orchestrate the underlying inflammatory cascade, while eosinophil trafficking is mediated by adhesion molecules and chemokines.
Fields of Study & Subjects
Asthma and respiratory diseases
IL-33
ST2
and ILC Pathways
Eosinophilic Esophagitis
Publication details
- Journal / source
- Turkiye Klinikleri eBooks
- Pages
- 257–272
- Publication date
- 1 January 2026
- Language
- EN
- Document type
- Book chapter