FINDING THE REAL ALLERGEN IN FOOD ALLERGY COMPONENT RESOLVED DIAGNOSIS

Component-resolved diagnosis is a molecular diagnostic approach that improves the precision of al-lergy testing and supports personalized management in food allergy (FA). It differs from extract-based assays by directly measuring immunoglobulin E (IgE) responses to individual allergenic components. These may include major or minor proteins that are purified from natural sources or produced recom-binantly. This method offers higher molecular resolution and provides clearer insight into sensitization mechanisms and clinical patterns. Component-resolved diagnostics (CRD), by enabling the distinction between genuine primary sensitization and cross-reactivity, substantially enhance diagnostic accuracy, facilitate the identification and risk stratification of patients predisposed to severe allergic reactions such as anaphylaxis, and help avoid the implementation of unnecessary dietary restrictions. It also supports clinicians in providing counseling and treatment options tailored to each patient’s molecular sensitization profile.