Chronic Obstructive Pulmonary Disease and Celiac Disease: Case Series of Comorbidities and Clinical Implications

Chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation and lung damage. Celiac disease (CD) can cause malabsorption and vitamin D deficiency. The coexistence of COPD and CD may worsen clinical outcomes. We present 3 COPD patients diagnosed with CD. Case 1: 47-year-old man with severe COPD and vitamin D deficiency. Case 2: 40-year-old woman with COPD exacerbation and low vitamin D. Case 3: 69-year-old man with COPD, cor pulmonale, anemia, and severe vitamin D deficiency. All patients had vitamin D deficiency, which may worsen lung function and prognosis. CD may contribute to malabsorption and systemic inflammation, compounding COPD severity. Early recognition and treatment of CD and vitamin D deficiency in COPD patients can improve clinical outcomes, reduce complications, and enhance quality of life. Assessment of gastrointestinal comorbidities and micronutrient status should be integrated into COPD management.