The First Case of Magnusiomyces clavatus Infective Endocarditis

Fungal endocarditis is a rare but often fatal condition. One such rare pathogen is Magnusiomyces clavatus, an ascomycetous fungus known to cause invasive disease in immunocompromised patients. This case report describes the first infective endocarditis case caused by M. clavatus in the literature, to the best of our knowledge. We present the case of a 50-year-old patient with a history of mitral valve replacement and tricuspid ring annuloplasty, who was admitted to the hospital with fever, shortness of breath and fatigue. He had undergone a surgical tracheostomy 10 months prior due to prolonged mechanical ventilation. A large vegetation caused by M. clavatus was detected on the mechanical prosthetic mitral valve. The patient refused surgical intervention and subsequently died during follow-up. Rare fungal infections should be considered in the etiology of infective endocarditis. In addition to their extremely high mortality rate, their prevalence is increasing.