Systemic Comorbidities and Apical Periodontitis: Influence on Endodontic Treatment Outcomes

Introduction: Systemic diseases are those that affect various parts of the body and not allow successful treatment repair due to the involvement of the immune system. At the oral level, these diseases manifest signs and symptoms, which, combined with the deficiency in the defense mechanisms of patients and alterations in the healing processes, directly in the defense mechanisms of patients and alterations in the healing processes, directly influence the effectiveness of treatments aimed at addressing endodontic pathologies. Objective: To analyze the association between apical periodontitis and various systemic diseases, as well as to evaluate its impact on the quality of life of patients. Materials and methods: Documentary approach research, cross-sectional and retrospective type, descriptive-analytical design and deductive method; following inclusion and exclusion criteria, 35 articles were included from 2016 to 2024. The information was obtained from databases such as PUBMED, Google Scholar, Science, Elsevier and Dialnet, Through PICO analysis, the keywords were obtained, MESH and DECS search terms were added. Results: All systemic diseases analyzed in this study can interfere with the repair process of periapical tissues after conventional root canal treatment. Conclusions: The systemic health of patients can affect favorable results in the treatment of endodontic infections, hence the importance of knowledge for the management of each disease and to promote preventive measures in the patients oral health.