CuMg Alloy Catalyst for Electrochemical Dopamine Detection

Electrochemical sensors offer rapid, cost-effective, and portable detection but often suffer from narrow linear ranges and poor long-term stability due to catalyst degradation or surface fouling. Herein, an electrochemical sensor employing a Cu1Mg1 bimetallic alloy catalyst was developed for highly sensitive and rapid detection of dopamine (DA). The Cu1Mg1 alloy, synthesized via a facile method, exhibited enhanced electrocatalytic activity due to synergistic effects between Cu and Mg, optimizing electron transfer and surface reactivity. The sensor demonstrated a wide linear range (0.01–100 μM) and excellent selectivity against common interferents. Notably, it achieved rapid response and superior long-term stability. Mechanistic studies revealed that Mg’s role in stabilizing Cu active sites and enhancing the conductivity was pivotal for broad-range detection. This work highlights the potential of Cu1Mg1 alloys as efficient catalysts for real-time, reliable neurotransmitter monitoring in biomedical applications, providing theoretical guidance for understanding the structure−property relationship.