Exercise Benefits for Progressive Supranuclear Palsy: A Narrative Review

Progressive Supranuclear Palsy (PSP) is a rare neurodegenerative disease characterized by the accumulation of 4R-tau protein aggregates in the cortex, brainstem and basal ganglia. The clinical ramifications are variable but often include a combination of vertical gaze palsy, axial rigidity, cognitive impairment and postural instability leading to frequent falls. Currently, PSP has no cure, and available pharmacological treatments offer limited benefit. Exercise-based therapy has emerged as a promising supportive approach for managing the functional decline in PSP. This narrative review summarizes the current evidence regarding the benefits of exercise interventions for individuals with PSP. A literature search was conducted using different medical databases to identify studies examining physiotherapy, rehabilitation, and structured exercise programs in PSP. The findings suggest that exercise interventions targeting balance, gait, and strength may improve motor performance, reduce fall risk, and enhance quality of life. However, evidence remains limited by small sample sizes, differing methodologies, and short follow-up. Despite these limitations, exercise appears to be a safe and valuable adjunct therapy for patients. Further research is needed to establish standardized exercise protocols and determine long-term outcomes.