The Effects of Statins in Patients with Endometrial Carcinoma on Cancer Progression, Recurrence, and Survival

Objective: Our pilot study was to evaluate the effects of statins on progression free survival (PFS) and 5-year, 10-year, and overall survival (OS) in patients with endometrial cancer (EC). Methods: We conducted a retrospective cohort study of 197 patients diagnosed with EC between 01/01/2008 – 10/31/2023 at a single academic institution in central Missouri. All stages were included. Patients were excluded from the study if they had inadequate records of treatment or follow up or received care outside of the university clinics. Cancer history, medication use, and patient demographics were collected from the electronic medical records and coded into REDCap using standardized operating procedures developed by the research team. Survival analysis was conducted using log rank and Kaplan-Meier estimates as well as Cox modeling for multivariate analysis. P-value