Research on the Correlation Between Periodontitis and Cerebral Small Vessel Disease

In recent years, the proposed "Oral-Brain- Axis" hypothesis has provided a new theoretical perspective on the relationship between oral health and cerebrovascular diseases. This study employs a combination of literature review and empirical research to explore the association between periodontitis and cerebral small vessel disease (CSVD). The research compared the periodontal status of patients with CSVD and non-CSVD patients, as well as tooth loss and periodontal indicators in patients with varying degrees of CSVD. Statistical validation was conducted using Spearman correlation analysis and Binary logistic regression analysis.The results indicate that the CSVD group had significantly higher levels of tooth loss and more severe periodontitis compared to the non-CSVD group. Patients with moderate to severe CSVD exhibited poorer oral health. Correlation analysis revealed a positive relationship between periodontal indicators, tooth loss, and the severity of CSVD. Further regression analysis confirmed that severe periodontitis is an independent risk factor for moderate to severe CSVD. Patients with moderate to severe periodontitis had a 1.501 times higher risk of developing moderate to severe CSVD compared to those with no or mild periodontitis.