Advances in the treatment of cancer-related fatigue in patients with advanced gastric cancer

Cancer-Related Fatigue (CRF) is one of the most common manifestations of Cancer-Related Distress (CRD). CRF in patients with advanced gastric cancer is a complex condition involving multiple contributing factors. It is closely associated with cancer cachexia caused by the tumor itself and is also related to various adverse effects following chemotherapy, targeted therapy, immunotherapy, and surgical treatment. In addition, psychosocial factors such as anxiety and depression significantly exacerbate patients' experience of fatigue. Current diagnostic and therapeutic strategies for CRF in advanced gastric cancer emphasize multidisciplinary comprehensive intervention. Western medical treatment primarily focuses on etiological management, while integrated traditional Chinese and Western medicine demonstrates unique advantages in holistic regulation. This integrative approach not only helps delay disease progression but also improves the quality of life of patients with advanced gastric cancer. This article aims to review the relevant etiological factors of CRF in advanced gastric cancer and recent research progress in etiological treatment through integrated traditional Chinese and Western medicine.