Benchtop NMR Signal Enhancement of Metabolites in Urine Extract using SABRE
Abstract
Metabolites in a urine extract are signal-enhanced by SABRE hyperpolarization and detected using a benchtop NMR spectrometer. Quantification by standard addition is demonstrated for endogenic urinary nicotinamide (vitamin B3). Even higher sensitivity is achieved in an automated setup for multi-scan SABRE experiments. This hyperpolarization scheme is able to expedite biomarker detection and quantification, while maintaining low infrastructural requirements.
Fields of Study & Subjects
Advanced NMR Techniques and Applications
Metabolomics and Mass Spectrometry Studies
Atomic and Subatomic Physics Research
Publication details
- Journal / source
- Repository KITopen (Karlsruhe Institute of Technology)
- Publication date
- 1 January 2026
- Language
- EN