Изучение импульсной активности в нейронах базолатеральной амигдалы, активированных энторинальной корой на модели болезни Паркинсона, в условиях протекции меланином

Parkinson’s disease (PD) is an incurable disease. In addition to classical movement symptoms, cognitive, affective, sleep disorders, and a wide range of autonomic symptoms are also found in PD. One of the important structures involved in the control of cognitive functions is the basolateral amygdala (BLA). Single-unit records from BLA neurons were performed using melanin in a model of Parkinson's disease (PD). Changes in the frequency of action potentials were investigated. In PD models, depressor and excitatory effects decreased. After the application of melanin, the values of both types of effects were restored. On the PD model, the frequency of action potentials increased by 7 times. After the application of melanin, the frequency of action potentials decreased, almost reaching normal levels. Thus, melanin helps restore the functional parameters of basolateral amygdala neurons.