Влияние 2-гидрокси-3-(2-(изобутилтио)этил)-4H-пиридо[1,2-a]пиримидин-4-она на регуляцию активности фермента моноаминоксидазы печеночной ткани

The present work studied the effect of 2-hydroxy-3-(2- (cyclopentylthio)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one (1) on the metabolism of biogenic amines (serotonin, norepinephrine, dopamine, phenylethylamine) and its impact on the activity of monoamine oxidases (MAO) in the liver. It is known that maintaining a normal level of these amines plays a key role in regulating emotional status by ensuring the stability of pre- and postsynaptic nerve impulse transmission. A deficiency of neurotransmitters can lead to the development of affective disorders, such as depression, fear, anxiety, and psychoemotional tension. Literature data indicate that one of the mechanisms of action of antidepressants is the stabilization of mental state through the inhibition of the monoamine oxidase (MAO) enzyme.