Impact of vitrification cryopreservation on the transcriptomic profile of metaphase II mouse oocytes
Abstract
BACKGROUND: Vitrification freezing has been shown to reduce mammalian oocyte developmental competence, and this has been strongly associated with abnormal mRNA expression in oocytes thawed by vitrification freezing. However the effect of vitrification freezing on the transcriptional machinery of oocytes examined by RNA sequencing has rarely been reported. OBJECTIVE: To study differentially expressed genes in mouse oocytes as a result of vitrification freezing. MATERIALS & METHODS: Differential gene expression was determined using DEseq2 (p-value
Fields of Study & Subjects
Reproductive Biology and Fertility
Reproductive biology and impacts on aquatic species
Sperm and Testicular Function
Publication details
- Journal / source
- Cryoletters
- Volume
- 47
- Issue
- 2
- Pages
- 108–119
- Publication date
- 6 February 2026
- Language
- EN