Critical commentary on initial lurasidone dosing strategies in acute schizophrenia
Abstract
This letter critically examines the study by Liu et al comparing 40 mg/day and 80 mg/day initial lurasidone doses in Chinese patients with acute schizophrenia. The analysis focuses on the study’s pragmatic design, safety outcomes, and early efficacy trends, including the paradoxical observation of greater weight gain at lower doses. By contextualizing the study’s findings within existing antipsychotic dosing literature, this commentary discusses implications for personalized treatment, while addressing methodological limitations. The letter aims to stimulate further research on optimal dosing strategies in real-world settings.
Fields of Study & Subjects
Schizophrenia research and treatment
Treatment of Major Depression
Mental Health and Psychiatry
Publication details
- Journal / source
- World Journal of Psychiatry
- Volume
- 16
- Issue
- 3
- Publication date
- 27 February 2026
- Language
- EN