Possible association between immunoglobulin A vasculitis and the development of schizophrenia: A case study

This case report describes a 41-year-old woman with a history of childhood immunoglobulin A vasculitis and adultonset schizophrenia, to the best of our knowledge, representing the first clinical observation suggesting a potential link between these conditions.Although current serological evaluations showed no active vasculitis, the case highlights a possible association, in line with research indicating an increased risk of schizophrenia in individuals with autoimmune disorders, including vasculitis.Mechanistically, immunoglobulin A vasculitis could hypothetically influence neuroimmune processes through transient effects on the blood-brain barrier or microvascular function, potentially contributing to pathways relevant to psychosis.Certain antipsychotic treatments are also known to interact with immune responses, supporting the rationale for further investigation.While causality cannot be inferred from a single case, this report underscores the importance of exploring immunoglobulin A vasculitis as a factor in schizophrenia pathogenesis and encourages longitudinal and mechanistic studies to better understand the potential neuroimmune mechanisms involved.