Clinical features and lifestyle habits of Parkinson’s disease individuals, non-manifesting GBA1 variant carriers and healthy controls

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Authors: Elisa Menozzi, Jane Macnaughtan, Micol Avenali, Marco Toffoli, Rosaria Calabrese, Pierfrancesco Mitrotti, Luca Gallo, Sara Lucas Del Pozo, Roxana Mezabrovschi, Sofia Koletsi, Nadine Loefflad, Selen Yalkic
+7 more Naomi Limbachiya, Franco Valzania, Francesco Cavallieri, Valentina Fioravanti, Giulia Toschi, Fabio Blandini, Anthony H.V. Schapira
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Abstract

Dataset including clinical features related to Parkinson's disease and lifestyle habits of three groups of individuals: 1) individuals with manifest Parkinson’s disease, 2) non-manifesting GBA1 variant carriers (individuals who are at increased risk of developing Parkinson’s disease because carriers of GBA1 genetic variants), and 3) healthy controls. This dataset has been generated as part of a cross-sectional study comparing the gut (fecal) microbiome composition, analyzed thorough shotgun metagenomic sequencing of the three groups. The study has evaluated associations between gut microbiome alterations and clinical features suggestive of Parkinson’s disease, in both Parkinson’s disease and non-parkinsonian individuals (GBA1 variant carriers and healthy controls).

Fields of Study & Subjects

Parkinson's Disease Mechanisms and Treatments Lysosomal Storage Disorders Research Gut microbiota and health

Publication details

Journal / source
University College London
Publication date
10 February 2026
Language
EN
Document type
Dataset