Hydrogel Therapeutics In Periodontal Regeneration: Advances In Material Design And Functionalization

Conventional therapies have poor therapeutic impact on periodontitis, a common chronic infectious disease caused by oral biofilm bacteria that causes gradual deterioration of periodontal supporting tissues.Hydrogels have great potential for use in the treatment of periodontitis and the regeneration of periodontal tissue because of their superior biocompatibility, three-dimensional extracellular matrix-like structure, and localized sustained-release properties.These properties can also support cell attachment, encourage cell proliferation and differentiation, and improve drug utilization efficiency.This article gives an overview of the different types of hydrogels, the active substances they can hold, and the properties and functions of these active substances after outlining the drawbacks of the available treatments for periodontitis and the special benefits of hydrogels in treating periodontitis and regenerating periodontal tissue.The most recent developments in the use of various common natural polymer hydrogels in periodontal tissue regeneration are then presented in the paper.The paper concludes by outlining the structural and property limitations of hydrogels today and suggesting possible fixes as well as future lines of research for periodontal tissue regeneration.