Pharmacogostical and Pharmacological Evaluation of Solanum Nigrum for diabetes induced vascular dementia

Background Solanum nigrum belongs to family Solanaceae.Makoi and Black nightshade are the common names for it.Chemical constituents commonly found in Solanum nigrum are glycoalkaloids, glycoproteins, polysaccharides, polyphenolic compounds such as gallic acid, catechin, protocatechuic acid, caffeic acid, epicatechin, rutin.It is known to possess various biological activities like antibacterial, antifungal, anti-inflammatory, anticancer, anti-oxidant, antipyretic and cytotoxic activity.Root, whole plant and fruits are used but of fresh leaves are not used as they possess anti-inflammatory property and used for the recovery of the memory disorder or dementia; therefore, they are not used for medicinal purposes.Reddish brown-colored fruits are used for edible purpose. Material & Methods:The study has been performed under the different parameters The Physicochemical parameter includes total Ash value, acid insoluble ash value, water soluble ash value moisture content, and foreign organic matter 2).Phytochemical investigation includes the Extraction of Solanum nigrum in different solvents in the increasing order of their polarity with Petroleum ether, chloroform, ethanol, distilled respectively and showed the occurrence of Alkaloids, carbohydrates, glycosides, tannins, Flavonoids, phenolic compounds.3).Diabetes induced vascular dementia animal model were used for the In-vivo the pharmacological screening carried out by measuring memory function in Morris water mazie and elevated Plus maze Results: Physicochemical parameters show total Ash value, acid insoluble ash value, water soluble ash value, moisture content, and foreign organic matter, which were determined to be not more than 8.98%, 1.5%, 7.8%, 3.2% and 0.25% in.effect of (ethanolic extract) were investigated by measuring.The active targets contribute a crucial part in the protection against oxidative stress, neurological inflammation or neurodegenerative disease.Interestingly, these proteins are also present in the brain, but their role in brain stroke is not clear.In this study we find the role of phytoconstituent and their involvement in the brain stroke and explore their potential as novel targets for cerebral protection