Efficacy of Elaeagnus multiflora and Cynanchum wilfordii Complex Extract on Male Lower Urinary Tract Symptoms: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Purpose: Purpose: Lower urinary tract symptoms (LUTS) in men substantially impair quality of life and are commonly treated with alpha-blockers or 5-alpha reductase inhibitors, which may cause adverse effects.Elaeagnus multiflora and Cynanchum wilfordii, traditional herbal remedies, have shown potential benefits in testosterone regulation and benign prostatic hyperplasia (BPH); however, clinical evidence supporting their efficacy in LUTS remains limited.This study evaluated the efficacy and safety of the E. multiflora and C. wilfordii complex (NET1701) in men with LUTS.Materials and Methods: Materials and Methods: In this randomized, double-blind, placebo-controlled trial, 100 men aged 40-80 years with moderate LUTS (International Prostate Symptom Score [IPSS] 8-19) were randomized to receive NET1701 (325 mg/d) or placebo for 12 weeks.The primary outcome was the change in total IPSS from baseline to 12 weeks.Secondary outcomes included IPSS subscores, maximum urinary flow rate (Qmax), post-void residual volume (PVR), serum testosterone levels, and safety.Results: Results: At 12 weeks, the NET1701 group showed a significantly greater reduction in total IPSS compared with placebo (-5.67±3.86 vs. -1.00±4.30;p