Efficient Synthesis of 1,1'-(2,2-diphenylethene-1,1-diyl) Bis(1H-indole) by the Reaction of (2,2-difluoroethene-1,1-diyl) Dibenzene) with Indole Derivatives
Abstract
We report a convenient two-step methodology for the synthesis of 1,1'-(2,2-diphenylethene-1,1diyl) bis(1H-indole).The cross-coupling reaction of 2,2-difluoro-1-iodoethenyl tosylate with 4 equiv of boronic acid in the presence of catalytic amounts of Pd(PPh3)2Cl2 and K3PO4 resulted in the formation of symmetrical di-coupling products ((2,2-difluoroethene-1,1-diyl) dibenzene) in high yields.The symmetrical products of the (diphenylethene-1,1-diyl) bis(1H-indole) were obtained in high yield by the reaction of the di-coupling product ((2,2-difluoroethene-1,1-diyl) dibenzene) with 2 equiv. of indole derivatives in the presence of base.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Synthesis of Indole Derivatives
Fluorine in Organic Chemistry
Publication details
- Journal / source
- Malaysian Journal of Chemistry
- Volume
- 28
- Issue
- 1
- Publication date
- 13 February 2026
- Language
- EN