Histological Changes of Skin Induced with Psoriasis and Treated with Aloe Vera Gel in Rats

Psoriasis is a common chronic immune-mediated inflammatory skin disease with features of epidermal hyperproliferation and infiltration of leukocytes. The current work was performed to assess the histopathological changes of imiquimod (IMQ) induced psoriatic skin lesions and investigate the beneficial therapeutic targets after topical application of Aloe vera (AV) gel in experimental rats. A total of 24 male Wistar albino rats were divided into four groups: G1 (healthy control), G2 (psoriasis-induced control), G3 (psoriasis + AV gel treatment), and G4 (psoriasis + Tazarotene treatment). Histological analysis revealed that AV gel significantly reduced keratosis, acanthosis, and perivascular inflammation, comparable to the standard Tazarotene treatment. The stratum corneum thickness was significantly decreased in treated groups. These findings suggest that AV gel holds promise as a natural therapeutic option for psoriasis management.