Association of Interleukin-6, Cystatin C, D-dimer Levels with Anxiety and Depression in People Living with HIV

Introduction: Certain inflammatory, hematological, immunological, and virological conditions contribute to chronic inflammation and have been associated with depression and anxiety in people living with human immunodeficiency virus (HIV) (PLWH). This study aimed to investigate the relationships between interleukin-6 (IL-6), cystatin C (Cys C) and D-dimer levels and the presence of depression or anxiety in PLWH.Material and Methods: People living with human immunodeficiency virus who had an HIV RNA level of 500.000copies/ mL at the time of diagnosis was found to be a significant predictive risk factor for future depression (p= 0.024; Odds ratio= 2.324; 95% CI= 1.116-4.839).However, no significant associations were observed between IL-6, Cys C, D-dimer and other inflammatory parameters and the presence of depression or anxiety.Conclusion: PLWH who present with high viremia at the time of diagnosis should be closely monitored for the development of depression.However, among PLWH who achieve virological success, inflammatory markers do not appear to be associated with depression or anxiety.