Hyalinizing clear cell carcinoma of the lung: A rare case with long-term follow-up

Introduction: Primary salivary gland-type lung cancers are extremely rare, accounting for less than 1% of all lung tumors. Hyalinizing clear cell carcinoma (HCCC) of the lung, an even rarer subtype, presents diagnostic challenges due to its similarity to other endobronchial lesions, such as carcinoid tumors or mucoepidermoid carcinoma. Here, we aimed to present a case of a 53-yearold male non-smoker who presented with recurrent respiratory symptoms. Initial chest X-ray showed consolidation, and subsequent computed tomography (CT) revealed a left lower lobe endobronchial nodule with postobstructive pneumonia. Positron emission tomography-CT imaging demonstrated mild F-18 fluorodeoxyglucose uptake, and bronchoscopy with biopsy led to the diagnosis of HCCC. The patient underwent a left lower lobectomy, and histopathological analysis confirmed the diagnosis. The fiveyear follow-up was unremarkable, with no signs of recurrence. This case underscores the importance of considering HCCC in the differential diagnosis of endobronchial lesions, particularly in non-smokers.