The Impact of genistein on oxidative stress biomarkers in erythrocytes: A study in IPD patients

The pathophysiology of Idiopathic Parkinson’s disease (IPD), a progressive neurodegenerative condition, is extensively affected by oxidative stress. IPD is a multifactorial disease in which oxidative stress damage the systemic cellular system, along with the central nervous system. However, the peripheral biomarkers imbalance and therapeutic responses in IPD remain restricted. In this study, erythrocytes from healthy control and IPD patients were used to evaluate the impact of Genistein on oxidative stress biomarkers. The assessment was conducted on medically appropriate blood samples collected from 95 subjects out of which (n=45) are healthy control and (n=50) are IPD patients. The impact of genistein were assessed against oxidative stress induced by 10mM H2O2, evaluated by quantifying the levels of MDA, GSH, SOD and Catalase after co-incubation of erythrocytes with genistein (10-7M to 10-5M) and H2O2. The outcomes showed elevated MDA levels and SOD activity (P