THERAPEUTIC APPROACH TO AGORAPHOBIA: PHARMACOLOGICAL AND COGNITIVE-BEHAVIORAL STRATEGIES

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Authors: Priscila Mara Pereira Coradini, Ryan Rafael Barros De Macedo, Igor Alves Savi, Anderson Ullisses Santana Soares, Luiz Otávio da Silva Flor De Lima, Silvana Costa Castro, Matheus Oliveira De Azevedo, Patrícia Natsumi Figueiredo Dohara, Luis Alexandre Lago Marchesan, Joana Paula Carvalho Correa, Camilli dos Santos Nascimento, Nailon de Morais Kois
+1 more Darla Maria da Silva Lima
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Abstract

Agoraphobia, currently recognized as an independent diagnostic entity, is characterized by intense fear and avoidance of situations in which escape is perceived as difficult or help unavailable. This disorder causes profound functional impairment, affecting approximately 2% of adolescents and presenting high rates of comorbidities and suicide risk. This narrative review analyzes recent scientific evidence on the management of agoraphobia, emphasizing the integration of pharmacotherapy and Cognitive-Behavioral Therapy (CBT). In the pharmacological domain, Selective Serotonin Reuptake Inhibitors (SSRIs) are established as first-line treatment, while the use of benzodiazepines should be restricted to the acute phase to avoid inhibition of therapeutic habituation. In the psychotherapeutic field, exposure techniques remain the gold standard, enhanced by technological innovations such as Virtual Reality Exposure Therapy (VRET) and self-guided digital interventions. The study also highlights the relevance of metacognitive beliefs in the maintenance of the disorder. It is concluded that a multidisciplinary and technologically integrated approach is essential to break the cycle of avoidance and promote sustained functional recovery.

Fields of Study & Subjects

Anxiety Depression Psychometrics Treatment Cognitive Processes Psychological Treatments and Assessments Digital Mental Health Interventions

Publication details

Journal / source
International Seven Journal of Multidisciplinary
Volume
5
Issue
1
Pages
e9058–e9058
Publication date
19 January 2026