Study of antifungal activity of (Z)-2, 2', 4, 4', 5, 5'-Hexahydroxy stilbene

Stilbenes constitute a prominent class of plant-derived secondary metabolites belonging to the polyphenolic family and are widely distributed in dietary sources such as grapes, peanuts, and related foods.These compounds occur in two geometric isomeric forms, namely trans-stilbene (E-form) and cis-stilbene (Z-form), both of which contribute significantly to biological activity.Naturally occurring stilbene derivatives, including resveratrol, pterostilbene, and combretastatin A-4, have been extensively studied for their diverse pharmacological properties, such as antimicrobial, anticancer, anti-inflammatory, and neuroprotective effects, along with their roles in preventing cardiovascular diseases, Alzheimer's disease, and diabetes.Among these, cis-stilbenes exhibit unique structural and physicochemical characteristics that render them valuable scaffolds in photochemistry, materials science, and medicinal chemistry.Recent studies have highlighted the enhanced antimicrobial potential of stilbenoid compounds.In the present study, a novel cis-stilbene derivative, (Z)-2,2′,4,4′,5,5′-hexahydroxy stilbene, was successfully synthesized for the first time via a single-step transformation from its precursor, (Z)-2,2′,4,4′,5,5′-hexamethoxy stilbene.The synthesized compound was subjected to spectral characterization and evaluated for its fungicidal activity against selected fungal pathogens, demonstrating its potential as a promising antifungal agent.