Evaluation of LC/MS Methods for Hydrophilic Metabolites to Enable Integration of Human Blood Metabolome Data

Mass Spectrometry 2026 Open access

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Authors: Yuri Imado, Masatomo Takahashi, Yuki Soma, Shunsuke Aburaya, Kohta Nakatani, Taizo Hanai, Takeshi Bamba, Yoshihiro Izumi
DOI: 10.5702/massspectrometry.a0188
Cited by: 1
References: 45

Abstract

extracts. Furthermore, we successfully estimated new concentration values for 29 metabolites without certified values in SRM 1950 using quantitative data from the four LC/MS methods. We objectively evaluated the performance of the four LC/MS methods and demonstrated that absolute quantification using SILIS is effective for integrating hydrophilic metabolite data in metabolomics.

Fields of Study & Subjects

Metabolomics and Mass Spectrometry Studies Gut microbiota and health Microbial Metabolic Engineering and Bioproduction

Publication details

Journal / source
Mass Spectrometry
Publisher
The Mass Spectrometry Society of Japan
Volume
15
Issue
1
Pages
A0188–A0188
Publication date
19 January 2026
Language
EN