ASAP1 gene InDel variants are associated with enhanced goat resistance against Brucella infection

Animal Bioscience 2026 Open access

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Authors: Xiaoyu Liu, Congliang Wang, Xiaoyuan Ren, Zhaofei Ren, Yanyan Li, Wangye Liu, Rongrong Li, Xiaoyue Song, Helin Li, Lei Zhang, Shenghui Chen, Xiaomin Du
+2 more Jinlian Hua, Haijing Zhu
DOI: 10.5713/ab.250722
Cited by: 2
References: 34

Abstract

OBJECTIVE: This study aimed to investigate the potential of the ASAP1 gene as a genetic biomarker for brucellosis resistance/susceptibility in goats. METHODS: This study collected samples from female Shaanbei white cashmere (SBWC) goats to investigate the association between the ASAP1 gene and brucellosis susceptibility. Peripheral blood mononuclear cells (PBMCs) were isolated from goats with various haplo types and Brucella statuses, and the association was evaluated using polymerase chain re action (PCR), quantitative reverse transcription (qRT)-PCR, and lipopolysaccharide (LPS) stimulation assays. RESULTS: The ASAP1 gene was expressed most in th e spleen, significantly more than in the kidney and heart (p

Fields of Study & Subjects

Brucella: diagnosis epidemiology treatment Prion Diseases and Protein Misfolding Milk Quality and Mastitis in Dairy Cows

Publication details

Journal / source
Animal Bioscience
Publisher
Asian Australasian Association of Animal Production Societies
Volume
39
Issue
7
Pages
250722–250722
Publication date
18 March 2026
Language
EN