The Pro-Inflammatory cytokines and vital physiological functions exploring among Iraqi ASD children: A comparative and correlation study

Autism is the most prevalent of the pervasive developmental disorders, which are more common in boys than in girls.In recent years, the effects of cytokine interactions as biomarkers for diseases have been studied in more detail.This justifies the present study, which aims to diagnose ASD based on pro-inflammatory cytokines and physiological functions.To determine whether pro-inflammatory cytokines and physiological functions are involved in the pathogenesis of ASD.Samples of ASD cases were recruited from the Children Protection Hospital's ASD Center in Baghdad.They were gathered over the course of four months, spanning from October 2023 to January 2024.The factors covered by the study include IL-4, INF-γ, and ABO/Rh blood systems, as well as some important pathophysiological tests.Our present findings suggest that IL-4 and INF-γ levels may serve as diagnostic biomarkers of ASD.Furthermore, blood group B and Rh+ve had the highest percentage in ASD healthy.These findings detected a significant decrease in ALT and AST levels.Additionally, the blood urea assay was recorded as significantly increased in ASD compared to healthy children.Correlation analysis showed a significant positive relationship between IL-4 and IFN-γ, as well as between IFN-γ and potassium (K) levels, between T3 and T4, and between ALT and AST.A negative correlation was also found between T4 and blood urea levels.Conclusion: This study underlines the significance of pro-inflammatory cytokines and physiological functions in Iraqi children with ASD.In particular, we observed low levels of proinflammatory cytokines (IL-4, INF-γ) and conducted a correlation analysis between immunity and hormonal and physiological indexes in children with ASD