Correlation between plasma Pentraxin-3 (ptx3) levels and Carotid Intima–Media Thickness (CIMT) in patients at intermediate to high cardiovascular risk

Globally, mortality is still largely driven by atherosclerotic cardiovascular disease, making early identification of silent or asymptomatic atherosclerosis particularly important in individuals with intermediate to high cardiovascular risk.Inflammation throughout the body contributes significantly to the development of atherosclerosis, and pentraxin three has been proposed as a biomarker that may reflect disease progression, although its clinical relevance still requires further confirmation.Carotid intima media thickness is widely recognized as a noninvasive method to evaluate the severity and advancement of atherosclerotic changes.The study employed an observational cross-sectional design to examine the correlation between plasma pentraxin-3 levels and carotid intima-media thickness in patients with intermediate to high cardiovascular risk as determined by a general risk assessment model.Participants underwent carotid ultrasound examination and blood sampling for pentraxin three analysis, and the data were evaluated using correlation analysis.The findings showed no meaningful association between plasma pentraxin three concentration and carotid intima media thickness in this patient group, whereas carotid intima media thickness demonstrated a clear positive relationship with increasing age and overall cardiovascular risk.In conclusion, plasma pentraxin three levels do not appear to be significantly related to carotid intima media thickness in individuals with intermediate to high risk of cardiovascular disease.