Comparison of ADC and Ktrans values with mitotic rate and histopathological subtypes of endometrial cancer

Endometrial cancer is the most common gynecological cancer in women, after breast, colon, and lung cancer.This study aims to analyze the comparison between ADC values and Ktrans values in patients with high and low risk subtypes of endometrial cancer and the mitotic rate of endometrial cancer.This study used a diagnostic test with a retrospective design.The sample population consisted of endometrial cancer patients who underwent pelvic MRI and hysterectomy or biopsy at Dr. Soetomo Regional General Hospital.The study population consisted of 65 patients.In this study, 47 low-risk endometrial cancer samples and 18 high-risk samples were obtained.The range of endometrial cancer Ktrans values was between 0.23-1.33min-1, while the range of ADC values was between 0.50-1.27x 10-3 mm2/s.The average Ktrans value was 0.58 min-1 with 34 samples with values below the average and 31 samples above the average.The average ADC value was 0.72 x 10-3 mm2/s with 38 samples below the average.Based on these figures, a diagnostic test using the Mann Whitney test was carried out, showing a relationship between ADC and histopathological subtypes of endometrial cancer, showing a p-value >0.05 (95% CI), which means that statistically there is no significant relationship between ADC and histopathological subtypes of endometrial cancer.A diagnostic test using a t-test revealed no statistically significant association between Ktrans and histopathological subtypes of endometrial cancer.Analysis of the relationship between ADC and the mitotic rate of endometrial cancer using the Spearman's rho correlation test revealed a statistically significant association between ADC and the mitotic rate of endometrial cancer, with a correlation coefficient of -0.34, indicating a weak negative correlation between the two variables.However, the analysis of the relationship between Ktrans and the mitotic rate of endometrial cancer was not significant.Based on diagnostic tests, the association between ADC and Ktrans with endometrial cancer histopathological subtypes and the association between Ktrans and the endometrial cancer mitotic rate was insignificant.Meanwhile, the association between ADC and the endometrial cancer mitotic rate was significant, with a weak negative correlation between the two variables.