Chitosan-Based Materials for Effective Wound Healing

Wound healing is a complex biological process calling for materials that improve tissue regeneration, control infections, and sustain a favorable environment for healing. Biopolymers are proven to be more effective than synthetic ones because of their exceptional biodegradability, biocompatibility, and antimicrobial properties. Chitosan, a naturally derived polymer, due to its antioxidant, regenerative, and antimicrobial properties, has emerged as a versatile candidate for wound healing applications. This chapter explores the versatile uses of chitosan-based materials in wound management, involving hydrogels, nanocomposites, films, sponges, and membranes. It emphasizes the synthesis, biological evaluation, and formulation methods of these materials and their role in promoting different phases of wound healing. By incorporating bioactive agents, nanoparticles, and synergistic polymers into chitosan matrices to improve the antimicrobial activity, mechanical strength, and therapeutic efficacy. This chapter highlights the potential of chitosan-based materials for effective wound healing and addresses both the opportunities and challenges in their clinical translation.