Recent Antiretroviral Therapy Models Implemented to Achieve Viral Suppression among People Living with Human Immunodeficiency Virus: A Systematic Review

This is a systematic review of interventions adopted to improve viral outcomes of people living with human immunodeficiency virus (PLHIV). A search was performed on Science Direct and NCBI to select peer-reviewed articles based on the inclusion criteria. Titles, abstracts and full text were screened and relevant articles were selected into the review. Financial incentives were found to improve viral suppression among PLHIV. Psychosocial intervention demonstrated varying virologic outcomes. Differentiated service delivery including task shifting, community ART and home-based ART had higher viral suppression compared to standard care. Technology-related interventions including personalized text messaging, and computer-based counseling improve viral suppression. Other interventions like integrated HIV care services and monitoring of drug resistance improved or maintained viral suppression. Many interventions have been adopted and have improved virologic outcomes across the globe. However, Other research should be conducted to ensure more robust evidence for optimizing virologic outcomes of PLHIV.