Surgical Management of Hypoglycemia in Non-Diabetic Patients

Hypoglycemia predominantly occurs in adults with diabetes mellitus; however, all patients with hypoglycemia without diabetes mellitus who present Whipple’s triad should undergo evaluation and targeted treatment. Depending on its etiology, non-diabetic hypoglycemia can be normoinsulinemic or hyperinsulinemic (insulinoma and hyperplasia of the islet cells, such as nesidioblastosis). To perform timely treatment, an accurate diagnosis is required, as it is crucial to understand the etiology in this group of patients. The basis for management is surgical resection when possible, which is curative in most cases.